In my capacity of elected Director in GERA-GEM and outgoing President of the Association of GEM National Teams (Global Entrepreneurship Monitor, GEM), Head of the GEM Research Program in Israel, Chair of the Board of Directors of the Association of Engineers, Architects and Graduates in Technological Sciences in Israel, and Chair of the Ira Center for Business, Technology and Society, I am pleased to present Israel’s report on "Entrepreneurship and National Innovation in the COVID-19 Era, GEM 2020/2021." Israel is one of the ten countries that established the GEM international research program in 1998, and has since participated in it continuously. GEM is an international, comparative, multiannual study of entrepreneurship. 43 countries participated in the study this year, a multinational and multiannual study that aims at providing assessments and annual metrics about emerging entrepreneurship and the entrepreneurial ecosystem in these countries. The uniqueness of the study stems, inter alia, from its focus on entrepreneurial behavior of individual entrepreneurs, not organizations, and from a database that relies on the direct collection of information, not on data from the governments of the various countries. The GEM study program has a large and up-to-date repository of data about global emerging and young entrepreneurship. For the last two years, the entire world and Israel have been facing the challenges of the COVID-19 pandemic, which is significantly affecting the world economy and changing the way countries approach entrepreneurship and innovation. The governments of Israel and other countries consider entrepreneurship and innovation as the key to overcoming national and personal economic crises. It should be noted that we are currently considering increasing the frequency of data collection to quarterly or monthly using digital means. This will enable us to more closely monitor entrepreneurship and innovation trends. This year too the study was conducted with the academic and financial sponsorship of the Ira Center for Business, Technology and Society and the Ministry of Economy and Industry via the Agency for Small and Medium-Sized Businesses. As a general observation. while COVID-19 has affected income levels and corporate survival rates, overall it made the economy more resilient to change and crisis, which in the long run seem to make for a healthy and sustainable economy.